SoBioS is an easy-to-run code to compute Sobol' indices for biological systems.

View the Project on GitHub americocunhajr/SoBioS

SoBioS - Sobol’ Indices for Biological Systems is an easy-to-run Matlab code used for Sobol’ indices-based global sensitivity analysis of Biological Systems. The implementation follows an educational style, to make its use very intuitive.

This package includes the following modules:

Software History

This code was developed as a pedagogical tool to teach the basics of global sensitivity analysis of biological systems via Sobol’ indices. A tutorial explaining the theory and practical aspects behind SoBioS package is provided in the following book chapter:

UQLab dependency

In order to use the SoBioS code, it is necessary to have UQLab package installed:

This external package is free for academic use.


Citing SoBioS

We kindly ask users to cite the following reference in any publications reporting work done with SoBioS:

   author    = {M. Tosin and A. M. A. C\ˆ{o}rtes and A. {Cunha~Jr}},
   title     = {A {T}utorial on {S}obol’ {G}lobal {S}ensitivity {A}nalysis {A}pplied to {B}iological {M}odels},
   editor    = {F.A.B. {da Silva} and N. Carels and M. {Trindade dos Santos} and F.J.P. Lopes},
   booktitle = {Networks in Systems Biology: Applications for Disease Modeling},
   publisher = {Springer International Publishing},
   address   = {Cham},
   year      = {2020},
   pages     = {93-118},
   doi       = {},


SoBioS is released under the MIT license. See the LICENSE file for details. All new contributions must be made under the MIT license.